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结节性淋巴细胞为主型霍奇金淋巴瘤(NLPHL)与经典型霍奇金淋巴瘤(CHL)虽有相似之处,但其流行病学、临床、病理及预后特征不同,故被独立进行分类。二者鉴别:在25%~70%的CHL瘤细胞中可检测到EBV,而在大多数NLPHL则不然。目前仅在亚洲及拉丁美洲的一些文献中报道了少数EBV+NLPHL病例,在北美地区尚无EBV+NLPHL发病率的大宗病例报道。故作者选取北美3个中心机构的302例NLPHL,包括145个儿童病例(≤18岁)及157个成人
Although there are similarities between nodular lymphocyte predominant Hodgkin’s lymphoma (NLPHL) and classical Hodgkin’s lymphoma (CHL), their epidemiological, clinical, pathological and prognostic features are different, sort. Identification of the two: EBV can be detected in 25% to 70% of CHL tumor cells, but not in most NLPHL. Currently only a few cases of EBV + NLPHL are reported in some Asian and Latin American literature and no large case of EBV + NLPHL incidence is reported in North America. Therefore, the author selected 302 North American NLPHL centers, including 145 children (≤18 years old) and 157 adults