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目的研究长期电磁辐射对大鼠学习记忆能力的影响。方法将通过八臂迷宫训练的16只健康成年清洁级Wistar雄性大鼠随机分为辐射组和对照组,每组8只。辐射组进行功率密度为10 mW/cm2的电磁辐射,每天6 h,每周6 d,连续8周。每周采用八臂迷宫实验测定大鼠的学习记忆能力。8周后,测定大鼠脑组织乙酰胆碱酯酶活力。结果辐射组大鼠每次迷宫实验耗时标准化数值、参考记忆错误次数以及工作记忆错误次数在第1～6周明显多于对照组大鼠(P<0.05),但第7、8周辐射组大鼠与对照组大鼠在迷宫实验耗时标准化数值、参考记忆错误次数以及工作记忆错误次数上并无明显差异。辐射组和对照组大鼠脑组织乙酰胆碱酯酶活力间比较,差异无统计学意义。结论 10 mW/cm2电磁辐射在短期可使大鼠的学习记忆能力下降,但长期作用对大鼠的学习记忆能力的影响可能有限。
Objective To study the effects of long-term electromagnetic radiation on learning and memory in rats. Methods Sixteen healthy adult Wistar male rats, trained by eight-armed maze, were randomly divided into radiation group and control group, with 8 rats in each group. Radiation group for electromagnetic radiation with a power density of 10 mW / cm2, 6 h per day, 6 d per week for 8 weeks. Eight-week maze test was used to determine the learning and memory abilities of rats. After 8 weeks, acetylcholinesterase activity in rat brain was measured. Results The time-standardized values of maze test, the number of reference memory errors and the number of errors in working memory in the radiation group were significantly more than those in the control group from the first week to the sixth week (P <0.05) There was no significant difference in the time-standardized values of maze test, the number of reference memory errors and the number of working memory errors between rats and control rats. Radiation group and control group rat brain acetylcholinesterase activity between the comparison, the difference was not statistically significant. Conclusion 10 mW / cm2 electromagnetic radiation can reduce the learning and memory ability of rats in short term, but the long-term effects on the learning and memory ability of rats may be limited.