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目的 :检测 35例食管癌患者 3p2 5 D3S10 38染色体位点的杂合缺失 ,为寻找此位点附近潜在的抑癌基因奠定基础。 方法 :微卫星 DNA- PCR-银染法检测 3p2 5 D3S10 38位点杂合缺失。结果:3p2 5 D3S10 38位点有 11例存在杂合缺失 (L OH) ,L OH率为 31.4 % ,此位点杂合缺失在各民族中均存在。结论:3p2 5 D3S10 38存在杂合缺失且有一定发生频率 ,可能与食管癌的发生有关 ,值得继续研究。
OBJECTIVE: To detect the heterozygous deletion of 3p25 D3S1038 in 35 esophageal cancer patients, and to lay a foundation for finding potential tumor suppressor genes near this site. Methods: The heterozygous deletion of 3p2 5 D3S10 38 locus was detected by microsatellite DNA-PCR-silver staining. Results: In the 3p2 5 D3S10 38 loci, there were 11 cases of LOH deletion and LOH rate of 31.4%. The heterozygous deletion in this locus existed in all ethnic groups. Conclusion: The heterozygous deletion of 3p2 5 D3S10 38 with a certain frequency of occurrence may be related to the occurrence of esophageal cancer, so it is worth further study.