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研究食管鳞癌组织中nm2 3基因表达与肿瘤生物学行为之间的关系.方法 :应用免疫组织化学S -P法检测 43例食管癌手术切除标本中nm2 3基因的表达水平.结果 :食管鳞癌组织中nm2 3基因表达阳性率为 74 4%( 3 2 /4 3 ) ,其表达水平与癌浸润深度和TNM分期有关 ( P“,”Objective:To study the correlation between nm23 gene expression and the biological behavior in esophageal carcinoma.Methods:The levels of nm23 gene expression were examined by S-P immunohistochemical method in 43 cases with esophageal squamous cell carcinoma.Results:74.4%(32/43) showed positive staining of nm23 in the lesions.The patients with regional lymph node metastasis showed higher levels of nm23 gene expression than those without metastasis.The expression of nm23 was associated with tumor invasion(P<0 05) or the progression of TNM staging(P<0 05) or the metastasis of lymph node.Conclusion:The expression of nm23 gene might be a prognostic indicator for advanced esophageal carcinoma,and the over-expression might suggest poor prognosis.