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目的:探讨环维黄杨星D对大鼠心肌缺血-再灌注损伤的保护作用。方法:SD大鼠30只,分为假手术组、模型组和环维黄杨星D干预组,造模后分别于缺血30min、再灌注60min,观察3组大鼠的血清和心肌组织丙二醛(MDA)含量、超氧化物歧化酶(SOD)的含量的变化。结果:与模型组比较,环维黄杨星D组血清及心肌组织MDA水平明显降低,SOD水平明显升高。结论:环维黄杨星D对大鼠心肌缺血-再灌注引起心肌损伤具有明显的保护作用,其机制可能与抑制脂质过氧化物生成、清除氧自由基相关。
Objective: To investigate the protective effect of cyclophosphamide D on myocardial ischemia-reperfusion injury in rats. Methods: Thirty SD rats were divided into sham-operation group, model group and cyclophosphamide D intervention group. After 30 min of ischemia and 60 min of reperfusion respectively, the levels of serum and myocardial C Aldehyde (MDA) content and superoxide dismutase (SOD) content changes. Results: Compared with the model group, the levels of MDA in serum and myocardium of D group were significantly decreased and the level of SOD was significantly increased. CONCLUSION: Cyclovirobuxine D has a significant protective effect on myocardial injury caused by myocardial ischemia-reperfusion in rats. The mechanism may be related to inhibition of lipid peroxides production and oxygen free radical scavenging.