目的:探讨甲氨蝶呤(MTX)3种用药途径治疗非破裂输卵管妊娠的疗效情况。方法:选择适宜病例150例,按数字随机法分为3组,治疗A组于宫颈1点和11点两点注射MTX 7 mg/kg,治疗B组超声引导下经阴道孕囊注射MTX 5～50 mg;对照组肌内注射MTX 10 mg/kg。结果:治疗A组总有效率84.0%,输卵管通畅率78.0%,与治疗B组比较,差异无统计学意义(P>0.05);与对照组比较,差异有统计学意义(P<0.05)。结论:宫颈注射较其他给药途径方法简单,疗效明显。 Objective: To investigate the efficacy of three routes of methotrexate (MTX) in the treatment of non-ruptured tubal pregnancy. Methods: One hundred and fifty cases were selected and randomly divided into three groups according to the number of randomization. Group A was treated with MTX 7 mg / kg at 1 o’clock and 11 o’clock in the cervix. MTX 5 ~ 50 mg; control group intramuscular injection of MTX 10 mg / kg. Results: The total effective rate of treatment group A was 84.0%, the fallopian tube patency rate was 78.0%. There was no significant difference between the two groups (P> 0.05). The difference was statistically significant (P <0.05). Conclusion: Compared with other routes of cervical injection, the method is simple and the curative effect is obvious.