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目的：研究nm23蛋白在喉癌组织中的表达意义。方法：应用免疫组织化学LSAB技术检测50例喉癌组织中nm23蛋白的表达。结果：nm23蛋白表达在癌旁粘膜组织中阳性率明显高于喉癌组织，差异有显著性（P＜0．05）；同时发现nm23蛋白表达与肿瘤大小、分化程度、浸润深度、淋巴结转移和复发显著相关（P＜0．01或P＜0．05）。结论：作者认为对喉癌患者检测nm23蛋白，对于判断肿瘤的生物学特性，预测淋巴结转移及评估临床预后有一定的指导作用和临床应用前景。
Objective: To study the expression of nm23 protein in laryngeal carcinoma. Methods: The expression of nm23 protein in 50 cases of laryngeal carcinoma was detected by immunohistochemistry LSAB technique. Results: The positive rate of nm23 protein in adjacent mucosa tissues was significantly higher than that in laryngeal carcinoma tissues (P <0.05). The expression of nm23 protein was correlated with tumor size, differentiation, depth of invasion, lymph node metastasis Recurrence was significantly correlated (P <0.01 or P <0.05). Conclusion: The authors believe that the detection of nm23 protein in patients with laryngeal cancer for the determination of biological characteristics of the tumor, lymph node metastasis prediction and evaluation of clinical prognosis have some guidance and clinical application prospects.