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目的 探讨尿液中端粒酶活性在尿路上皮癌的诊断和监测复发中的意义。方法 采用PCR ELISA法对 5 4例尿路上皮癌尿液中端粒酶活性进行了检测 ,并观察了其中 2 3例术后尿液中端粒酶活性的变化 ,以 4 6例良性泌尿系统疾病患者作为对照组。结果 尿路上皮癌病人尿液中端粒酶活性明显增高 (P <0 0 0 1) ,肿瘤切除后恢复正常 ,在膀胱镜发现肿瘤复发前再次上升 ;随着肿瘤恶性程度的增加尿液中端粒酶活性逐渐升高 ;术前尿液中端粒酶活性与早期复发无关。结论 尿液中端粒酶活性的检测在尿路上皮癌的诊断中有参考价值 ,与肿瘤恶性程度有关 ,敏感度高于膀胱镜检查 ,可能成为监测尿路上皮癌复发的重要辅助手段
Objective To investigate the significance of the telomerase activity in urine in the diagnosis and recurrence of urothelial carcinoma. Methods The telomerase activity in urine of 54 cases of urothelial carcinoma was detected by PCR-ELISA. The changes of telomerase activity in 23 cases of postoperative urinalysis were observed. A total of 46 cases of benign urinary system Disease patients as a control group. Results The urinary telomerase activity was significantly increased in patients with urothelial carcinoma (P <0.01). The tumor returned to normal after resection of the tumor. The cystoscopy increased again before tumor recurrence. With the increase of malignancy, Telomerase activity gradually increased; preoperative urine telomerase activity has nothing to do with early recurrence. Conclusion The detection of telomerase activity in urine has a reference value in the diagnosis of urothelial carcinoma, which is related to the degree of tumor malignancy and the sensitivity is higher than that of cystoscopy, which may be an important aid in monitoring the recurrence of urothelial carcinoma