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已知,铅中毒时尿中的δ-ALA和粪卟啉增加,但是铅中毒时生理性离子的变化和有关的酶活性之间的关系,报道的却很少。作者用雄性大鼠一次给予醋酸铅溶液0、5、50或200mg/kg,以阐明铅对大鼠血清和尿中钠、钾浓度和肾脏(Na~++K~+)ATP酶活性的影响,同时也检查了给铅大鼠对醛固酮、血管紧张素及血管加压素的反应。实验结果表明,大鼠的尿量和尿中钠和钾的排泄量随经口所给的铅的对数剂量呈线性增加,而尿钠与铅量的相关比尿钾与铅量的相关要更明显些。给铅后六小时尿钠排出最高,约为对照组的两倍。尿量在给铅后六小时最多,
It is known that urinary δ-ALA and coproporphyrin levels increase during lead poisoning, but the relationship between changes in physiological ions and related enzyme activities during lead poisoning is poorly reported. In order to clarify the effect of lead on the concentration of sodium and potassium in serum and urine and the activity of Na ~ + + K ~ + ATPase in rats, the rats were given 0, 5, 50 or 200 mg / The lead rats were also tested for aldosterone, angiotensin and vasopressin response. The experimental results show that the urine output of urine and urinary sodium and potassium excretion linear with the logarithmic dose of lead given by mouth, and the correlation between urinary sodium and lead than urinary potassium and lead related More obvious. Six hours after lead urinary sodium excretion was the highest, about double the control group. Urine output up to six hours after giving lead,