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目的观察育龄妇女中实行环磷酰胺治疗对卵巢损伤的临床疗效。方法选取医院风湿免疫科诊治的40例风湿病女性,依据治疗方式不同将其中30例分为B组与C组,C组实行环磷酰胺治疗,B组实行激素治疗,将同期的10例健康者作为A组,观察3组卵巢大小、雌激素等指标变化情况。结果环磷酰胺用药C组雌二醇低于A组、B组,环磷酰胺用药C组促卵泡激素高于A组,差异均有统计学意义(P<0.05)。结论风湿病女性患者实行环磷酰胺疗法可能损害育龄妇女卵巢功能,雌激素与月经失衡是主要表现,此外单独使用激素也会影响女性月经,但需进一步验证环磷酰胺与激素联用是否会增加月经紊乱情况。
Objective To observe the clinical effect of cyclophosphamide treatment on ovarian injury in women of childbearing age. Methods Forty patients with rheumatism admitted to the department of rheumatology and immunization of the hospital were divided into group B and group C according to different treatment methods. Group C was treated with cyclophosphamide, group B was treated with hormone therapy, 10 cases were healthy As a group, observe ovarian size, estrogen and other indicators changes in three groups. Results The serum estradiol levels of cyclophosphamide group C were lower than those of group A, group B and cyclophosphamide group C were higher than those of group A, the difference was statistically significant (P <0.05). Conclusion Cyclophosphamide therapy may affect the ovarian function of women of reproductive age in women with rheumatic diseases. Estrogen and menstrual imbalance are the main manifestations. In addition, hormones alone may affect women’s menstruation. However, it is necessary to further verify whether cyclophosphamide combined with hormones will increase Menstrual disorders.