基因疫苗作为第3次疫苗革命的新产物,已经体现出明显优势。美国食品药品管理局(FDA)规定其在临床应用前需进行体内药物代谢动力学实验,即定量研究其在体内的吸收、分布、代谢、排泄过程,为疫苗的实验室基础和临床研究提供参考资料,本文将对基因疫苗的药物代谢动力学研究现状作一概述。 As a new product of the third vaccine revolution, genetic vaccines have shown obvious advantages. The United States Food and Drug Administration (FDA) prescribes its pharmacokinetics in vivo before clinical application, that is, to quantitatively study its absorption, distribution, metabolism and excretion in the body, and provide a reference for the laboratory foundation and clinical research of the vaccine Data, this article will give an overview of the current status of gene vaccine pharmacokinetics.