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洛非帕明(lofepramine)是一种三环类抗抑郁药,其结构与丙咪嗪相似,它大量代谢为地昔帕明(脱甲丙咪嗪)。它的抗抑郁作用似起因于抑制摄入而促进去甲肾上腺素神经传递,也可能促进5-羟色胺神经传递。它对伴有焦虑的不同程度抑郁病人的综合疗效堪与丙眯嗪、阿米替林、氯米帕明、麦普替林和米安舍林相比拟。口干是使用洛非帕明常用治疗剂量时最常见的副作用,但口干及其它抗胆碱能副作用的发生率较丙咪嗪为低。洛非帕明对心功
Lofepramine, a tricyclic antidepressant with a structure similar to imipramine, is metabolized in large quantities to desipramine (desipramine). Its antidepressant effects appear to promote norepinephrine neurotransmission as a result of ingestion of inhibition and may also contribute to serotonergic neurotransmission. Its combined effect on depressive patients with varying degrees of anxiety is comparable to that of propimolamine, amitriptyline, clomipramine, maprotiline, and mianserin. Dry mouth is the most common side effect when using the usual therapeutic dose of clofibrate, but the incidence of dry mouth and other anticholinergic side effects is lower than imipramine. Losopamil on heart function