慢性阻塞性肺病(简称慢阻肺 COPD),在呼吸系统疾病中占有重要地位,一方面由于发病率高,另一方面病变范围广,肺功能损害明显,容易导致肺心病。慢阻肺的主要病理改变在呼吸道,尤其多发生于内径2mm 或以下的细支气管,造成管腔狭窄,气道阻力增高。肺闭合气量测验能较敏感的反映细气道阻塞情况,但该项测验国内仅有少数单位开展,大多数医院还停留在一般通气功能测验水平,一般通气功 Chronic obstructive pulmonary disease (COPD) plays an important role in respiratory diseases. On the one hand, due to its high incidence, on the other hand, it has a wide range of pathological changes and obvious pulmonary function impairment, which easily lead to pulmonary heart disease. The main pathological changes in COPD are in the respiratory tract, especially in the bronchioles with an inner diameter of 2mm or less, resulting in stenosis and increased airway resistance. Pulmonary closed breath test can reflect the sensitivity of small airway obstruction, but the test carried out only a few units in the country, most hospitals still remain in the general ventilation function test level, the general ventilation function