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目的:采用不同的实验性胃溃疡模型以探讨九灵胃康胶囊的药理作用。方法:分别制造幽门结扎胃溃疡、应激性胃溃疡、醋酸灼伤胃溃疡和利血平型胃溃疡动物模型,以九灵胃康胶囊和雷尼替丁对照治疗。结果:连续7 d灌胃给予九灵胃康胶囊1.0,0.5,0.25 g·kg-1·d-1,均能明显抑制幽门结扎引起的胃溃疡;一次性灌胃给药1.6,0.8,0.4 g·kg-1·d-1,能明显抑制小鼠应激性胃溃疡;分别连续灌胃14 d及6 d,可明显抑制醋酸灼伤和利血平型胃溃疡;九灵胃康胶囊能明显抑制胃液量, 降低胃液酸度和胃蛋白酶排出量。结论:九灵胃康胶囊具有明显的抑制实验性胃溃疡的作用,这种作用主要是通过抑制胃蛋白酶的排出和降低游离酸实现的。
Objective: To explore the pharmacological effects of Jiuling Weikang Capsules by using different experimental gastric ulcer models. METHODS: Animal models of pylorus-ligated gastric ulcer, stress gastric ulcer, acetic acid-burning gastric ulcer and reserpine-induced gastric ulcer were made, and were treated with Jiuling Weikang capsule and ranitidine control. Results: Jiulingweikang capsules were given with 1.0, 0.5, 0.25 g·kg-1·d-1 by gavage for 7 consecutive days, all of which could significantly inhibit the gastric ulcer caused by pylorus ligation; One-time intragastric administration 1.6, 0.8, 0.4 g · kg-1 · d-1, can significantly inhibit the stress gastric ulcer in mice; continuous gavage 14 d and 6 d, respectively, can significantly inhibit the acetic acid burn and reserpine-type gastric ulcer; Jiuling Weikang capsule can It significantly inhibits the amount of gastric juice and reduces gastric acidity and pepsin excretion. Conclusion: Jiuling Weikang Capsule has obvious inhibitory effect on experimental gastric ulcer. This effect is mainly achieved by inhibiting the excretion of pepsin and reducing free acid.