198 8年在使用ｂ型流行性感冒 (流感 )嗜血杆菌 (Ｈｉｂ)联合疫苗前 ,Ｈｉｂ是引起 5岁以下儿童细菌性脑膜炎和其它严重侵袭性疾病的主要病因。 1991年开始要求 2月龄儿童接种Ｈｉｂ联合疫苗 ,到 1996年 5岁以下儿童由Ｈｉｂ引起的侵袭性疾病的发病率下降了 99%以上。本文提供 198 years ago Hib was the leading cause of bacterial meningitis and other serious invasive diseases in children under five years of age before the Hib vaccine (b) was used. In 1991, two-month-old children were required to receive the Hib combination vaccine. By 1996, the incidence of Hib-induced invasive disease in children under five years of age had dropped by more than 99%. This article provides