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本实验以绒毛、蜕膜组织细胞培养为模型 ,用放射免疫测定方法 ,观察了双炔失碳酯对绒毛、蜕膜组织细胞分泌功能的影响。结果 :培养的绒毛、蜕膜组织细胞中加入系列浓度的双炔失碳酯后 2 4和 48h,h CG、E2 、P均明显降低 (P<0 .0 1 ,P<0 .0 5 ) ,PGF2α明显增高 (P<0 .0 1 ,P<0 .0 5 )。表明 ,双炔失碳酯可直接作用于人绒毛、蜕膜组织 ,抑制h CG、E2 、P的产生 ,刺激 PGF2α的合成。结果提示 ,绒毛、蜕膜是双炔失碳酯抗早孕时 ,主要作用环节之一。
In this study, villi and decidua tissue cell culture as a model, the use of radioimmunoassay method to observe the effect of anordrin on the villi and decidual cell secretion. RESULTS: At 24 and 48 h after administration of a series of concentrations of anordrin, the values of hCG, E2 and P were significantly decreased (P <0.01, P <0.05) in cultured villus and decidual cells. , PGF2α was significantly higher (P <0.01, P <0.05). The results showed that anordrin can directly act on human villi and decidua and inhibit the production of hCG, E2, P and stimulate the synthesis of PGF2α. The results suggest that villi, decidua is an anordrin ester anti-early pregnancy, one of the main role.