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目的探讨单侧坐骨海绵体肌损伤是否会引起勃起功能障碍。方法选用生殖期雄性大白鼠30只,随机分为单侧手术组(20只),双侧手术组(5只)和非手术组(5只)。单侧手术组切断一侧坐骨海绵体肌;双侧手术组切断双侧坐骨海绵体肌。手术后1周选用育龄期雌性大白鼠30只随机与上述三组一一配对饲养,观察2个月。了解三组配对雌鼠受孕情况,并通过对生育的影响推断勃起功能障碍。结果单侧手术组雄鼠死亡2只,雌鼠18只受孕,受孕率94．7％。双侧手术组雄鼠死亡1只,雌鼠5只均未受孕,受孕率为0。非手术组5只均受孕,受孕率100％。单侧手术组与双侧手术组雌鼠受孕率情况比较有非常显著性差异(P<0．001)。而与非手术组比较差异无统计学意义(P>0．05)。结论切断雄鼠单侧坐骨海绵体肌不导致永久性勃起功能障碍及不育。
Objective To investigate whether unilateral ischial cavernous muscle injury can cause erectile dysfunction. Methods Thirty male reproductive period rats were randomly divided into unilateral surgery group (n = 20), bilateral surgery group (n = 5) and non-surgery group (n = 5). Unilateral sciatic muscle was cut off in the unilateral surgery group. The bilateral ischialysis muscle was cut off in the bilateral surgery group. One week after operation, 30 female mice of child-bearing age were randomly selected and paired with the above three groups and observed for 2 months. Understand the fertilization of three groups of female mice, and infer the erectile dysfunction through the impact on fertility. Results There were 2 males died in unilateral surgery and 18 females in pregnancy. The pregnancy rate was 94.7%. Two males died in the bilateral surgery group and five females were not pregnant, the pregnancy rate was zero. Non-surgical group 5 were pregnant, pregnancy rate 100%. There was a significant difference in the pregnancy rate between unilateral surgery group and bilateral surgery group (P <0.001). There was no significant difference between the two groups (P> 0.05). Conclusion Severing the unilateral sciatic cavernous muscle of males did not result in permanent erectile dysfunction and infertility.