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谷胱甘肽是一个由谷氨酸、半胱氨酸及甘氨酸组成的三肽,具有抗氧化和解毒等功能。近年来研究发现谷胱甘肽的胆汁外排是生成非胆汁酸依赖型胆汁流的重要驱动力,谷胱甘肽的胆汁外排受阻可引起胆汁淤积。本文对谷胱甘肽的肝脏转运通路及其在胆汁淤积中的作用的研究进展进行综述。基于谷胱甘肽对胆汁流的驱动作用,增强谷胱甘肽的胆汁外排转运可望成为胆汁淤积防治的新靶点。
Glutathione is a tripeptide composed of glutamic acid, cysteine and glycine, which has functions of antioxidation and detoxification. In recent years, studies have found glutathione excretion of bile is to generate non-bile acid-dependent bile flow an important driving force, glutathione bile excretion blocked can cause cholestasis. This review summarizes the progress of hepatic transport pathway of glutathione and its role in cholestasis. Based on the glutathione-driven role of bile flow, enhanced glutathione bile efflux transport is expected to become a new target for the prevention and treatment of cholestasis.