论文部分内容阅读
目的 研究中国健康志愿者 po福辛普利后的药代动力学。 方法 10名男性健康受试者 po福辛普利 2 0mg后 ,用LC/MS/MS法测定不同时间血浆中活性代谢物福辛普利拉浓度 ,SRM方式选择性检测待测物的特征碎片离子 ,full scanms2 方式检测内标物的碎片离子。结果 本法线性良好 ,精密度、准确度、回收率均符合要求。测得的主要药代动力学参数为 :T1/2 =(6 6± 1 2 )h ,Tmax=(3 7± 1 1)h ,Cmax=(45 1 9± 2 5 1 2 )ng·mL-1,AUC0 -∞ =(35 78 4± 2 2 31 2 )h·ng·mL-1。结论 本实验测得的Tmax,Cmax和AUC0 -∞ 均高于文献报道的白人受试者的参数值 ,而T1/2 显著低于文献值。
Objective To study the pharmacokinetics of fosinopril in Chinese healthy volunteers. Methods Twenty fosinopril 20 male volunteers were enrolled in this study. Fosinopril concentration in plasma was determined by LC / MS / MS at different time points. SRM was used to detect the characteristic fragments Ion, full scanms2 way to detect the internal standard fragment ions. The results of this method is good linearity, precision, accuracy, recovery rate are in line with the requirements. The main pharmacokinetic parameters measured were T1 / 2 = (6 6 ± 1 2) h, Tmax = (37 ± 1 1) h and Cmax = (45 1 9 ± 2 5 1 2) ng · mL -1, AUC0-∞ = (35 78 4 ± 2 2 31 2) h · ng · mL-1. Conclusion The Tmax, Cmax and AUC0-∞ measured in this study are higher than those reported in the literature of white subjects, while T1 / 2 is significantly lower than the literature values.