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目的探索绝经后易跌倒骨质疏松患者干预治疗的成本-效益关系。方法对绝经后高危跌倒患者应用阿仑膦酸钠+钙尔奇D进行干预,运用Markov模型、增量成本-效益比分析干预后的成本-效益。结果经3年干预治疗后,干预组的腰椎L2-4骨密度为(0.944±0.114)g/cm2,股骨颈骨密度为(0.741±0.153)g/cm2,大转子骨密度为(0.631±0.152)g/cm2,骨密度值均显著性提高。干预3年并运用模型预测10年与对照组相比,治疗组平均每例净节省成本1732元,净增质量调节生命年(quality adjusted life years,QALYs)0.042年,每获得1个QALY的费用为41238元。结论在抗骨质疏松药物干预成本适度提高的基础上,QALY有所增加,改善了患者生活质量。
Objective To explore the cost-benefit relationship of post-menopausal patients with fallopian osteoporosis. Methods The patients with high risk of falling in postmenopausal patients were treated with alendronate sodium and Calcium D, and the Markov model was used to analyze the cost-effectiveness of intervention after incremental cost-benefit analysis. Results After three years of intervention, the lumbar L2-4 BMD of the lumbar spine was (0.944 ± 0.114) g / cm2, the femoral neck BMD was (0.741 ± 0.153) g / cm2 and the BMD of the BMD was (0.631 ± 0.152) ) g / cm2, bone mineral density values were significantly improved. Intervention for 3 years and using models to predict 10-year net benefit savings of 1732 yuan for each treatment group compared with control group, quality adjusted life years (QALYs) 0.42 for each QALY received For 41238 yuan. Conclusion Based on the modest increase of anti-osteoporosis intervention cost, QALY increased and the quality of life of patients improved.