【摘 要】
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Signaling pathways in innate and adaptive immunity play vital roles in pathogen recognition and the func-tions of immune cells.Higher-order assemblies have recently emerged as a central principle that governs immune signaling and,by extension,cellular com
【机 构】
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Department of Biological Chemistry and Molecular Pharmacology,Harvard Medical School,and Program in
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Signaling pathways in innate and adaptive immunity play vital roles in pathogen recognition and the func-tions of immune cells.Higher-order assemblies have recently emerged as a central principle that governs immune signaling and,by extension,cellular communi-cation in general.There are mainly two types of higher-order assemblies:1) ordered,solid-like large supramolecular complexes formed by stable and rigid protein-protein interactions,and 2) liquid-like phase-separated condensates formed by weaker and more dynamic intermolecular interactions.This review covers key examples of both types of higher-order assemblies in major immune pathways.By placing emphasis on the molecular structures of the examples provided,we dis-cuss how their structural organization enables elegant mechanisms of signaling regulation.
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