目的　量化评价心理社会应激因素对人群健康不同损害程度的作用强度。方法　以四川省简阳市三组人群 978人 (门诊病例 177例 ,住院病例 2 14例及健康对照 5 87人 )为研究对象 ,进行多组病例对照研究。分别收集一般人口学特征 ,用各量表测量心理社会应激因素及健康损害程度。进行秩和检验 ,方差分析 ,聚类分析 ,多类结果logistic回归模型拟和以及有序结果logistic回归模型拟和。结果　有序结果logistic模型示 ,负性事件刺激量OR =1.335 (P <0 .0 1)。社会支持利用对健康损害程度有保护作用 (OR =0 .5 13)。结论　负性生活事件刺激量是危害综合健康的主要因素 ,与健康的损害程度成剂量 效应关系 ;社会支持利用是健康的维护因素。 Objective To quantify the effect of psychosocial stress factors on the degree of harm to people’s health. METHODS: A total of 978 (three out of 177 outpatients, 214 inpatients and 587 healthy controls) were selected as the study subjects in Jianyang City, Sichuan Province. Multiple case-control studies were conducted. The general demographic characteristics were collected separately, and the scales were used to measure psychosocial stress factors and health impairment levels. Rank sum test, analysis of variance, cluster analysis, simulation of multivariate logistic regression models, and logistic regression models with ordered results were performed. Results The logistic model of the ordered results showed that the negative event stimulus was OR = 1.335 (P < 0.01). Social support has a protective effect on the degree of health impairment (OR = 0.55). Conclusion Negative life event stimuli is the main factor that harms general health, and it has a dose-effect relationship with the degree of health damage; social support utilization is a healthy maintenance factor.