论文部分内容阅读
目的探讨肺炎支原体(MP)感染与儿童咳嗽变异性哮喘(CVA)发生的关系。方法利用计算机在中国期刊网、万方数据库和重庆维普数据库中检索MP感染与儿童CVA发生的相关文献,并应用RevMan 5.0软件对符合儿童MP感染与儿童CVA发生关系的研究纳入标准的文献进行异质性检验和效应值的合并,同时进行各文献的敏感性分析和发表偏倚的评估,最后给出Meta分析结果的森林图。结果根据文献纳入标准,对计算机自动检索的文献进行分析,结果共纳入MP感染与儿童CVA关系研究的相关文献14篇,并来源于中国的11个地区。其中CVA组940例,对照组961例。对MP感染与儿童CVA发生关系的研究进行异质性检验,结果提示各研究之间无异质性(P>0.05),故采用固定效应模型进行分析,结果各研究的合并OR值(95%CI)为4.54(3.61～5.71)(Z=12.98,P<0.000 01)。利用随机效应模型再次进行合并分析,各研究的合并OR值(95%CI)为4.49(3.57～-5.66)(Z=12.75,P<0.000 01),提示各研究间结果稳定。漏斗图结果提示各研究的形状基本对称,呈倒漏斗状,提示各研究无发表偏倚。结论 MP感染与儿童CVA的发生密切相关。
Objective To investigate the relationship between Mycoplasma pneumoniae (MP) infection and the occurrence of cough variant asthma (CVA) in children. Methods A computer was used to search the related literature about MP infection and CVA in children in China by means of the Chinese Journal Net, Wanfang Database and Chongqing Vip Database. RevMan 5.0 software was used to study the relationship between MP infection in children and CVA in children. Qualitative test and effect value of the merger, while the literature on the sensitivity analysis and publication bias assessment, and finally give the results of the forest meta-analysis of the map. Results According to the inclusion criteria of the literature, the computer-based automatic retrieval of the literature was analyzed. Results There were 14 articles about the relationship between MP infection and CVA in children and 11 of them were from China. Among them, 940 cases were in CVA group and 961 cases in control group. Heterogeneity test was used to study the relationship between MP infection and CVA in children. The results showed that there was no heterogeneity between the studies (P> 0.05). The fixed effect model was used to analyze the results. The combined OR of each study was 95% CI) was 4.54 (3.61 to 5.71) (Z = 12.98, P <0.000 01). The combined OR analysis (95% CI) was 4.49 (3.57-5.66) for each study (Z = 12.75, P <0.000 01) using the random effects model again, suggesting a stable outcome across studies. Funnel results suggest that the shape of each study was basically symmetrical, was inverted funnel, suggesting that the study published no bias. Conclusion MP infection is closely related to the occurrence of CVA in children.