目的　探讨晚期原发性肝癌的治疗方法。方法　应用FUdR、复方丹参联合苦参碱类药物治疗原发性肝癌患者 3 3例 ,观察疗效与生存期及毒性反应。结果　客观缓解率 18.2 % ,中位生存期 5 .3个月 ,KPS评分明显改善 42 .4% ,仅 4例患者出现轻度毒性反应。结论　FUdR、复方丹参联合苦参碱类药物方案是晚期原发性肝癌的较好治疗方法 ,值得推广应用。 Objective To investigate the treatment of advanced primary liver cancer. Methods Forty-three patients with primary hepatocellular carcinoma were treated with FudR and Fufang Danshen combined with matrine, and their efficacy, survival and toxicity were observed. Results The objective response rate was 18.2%. The median survival time was 5.3 months. The KPS score was significantly improved by 42.4%. Only 4 patients showed mild toxicity. Conclusions FUdR and compound Salvia miltiorrhiza combined with matrine are the best treatment for advanced primary liver cancer, which is worth popularizing and applying.