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患者,男,33岁,发现腰部肿物2个月,行肿物切除病理提示为非霍奇金淋巴瘤,T细胞,免疫母细胞,血象大致正常,骨髓可见2%肉瘤细胞,诊断:非霍奇金淋巴瘤T细胞,Ⅳ期。予CHOP(环磷酰胺、阿霉素、长春新碱、强的松)等方案化疗4个月后,于1998-04行激活骨髓加自体外周血干细胞移植并联用重组白细胞介素2治疗。预处理方案为MACC方案(马法兰、阿糖胞苷,环磷酰胺,环己亚硝脲),移植+10d,中性粒细胞>0.5×109L-1,移植+16d,血小板>50×109L-1。移植+6d出现发热,血培养为大肠埃希秆菌,经抗生素治疗体温正常,症状消失。随访至今已10年10个月,仍无病生存,工作及生活正常。
The patient, male, 33 years old, had a lumbar mass 2 months and had a histopathologic diagnosis of non-Hodgkin’s lymphoma. T cells, immunoblasts and blood were roughly normal. 2% of sarcoma cells were visible in the bone marrow. Diagnosis: Hodgkin’s lymphoma T cells, stage IV. After 4 months’ regimen of CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) and other regimens, bone marrow plus autologous peripheral blood stem cell transplantation was activated in 1998-04 and treated with recombinant interleukin-2. The pretreatment protocol consisted of MACF (melphalan, cytarabine, cyclophosphamide and cycloheximide). After 10 days of transplantation, neutrophils> 0.5 × 109 L-1, 1. Transplant +6 d fever, blood culture for Escherichia coli, antibiotics normal temperature, the symptoms disappear. Follow-up has been 10 years and 10 months, still no disease survival, work and life are normal.