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目的:为研究去甲氧柔红霉素的抗白血病作用。方法:应用以去甲氧柔红霉素为主组成的联合方案治疗了难治性、复发性急性白血病21例。结果:11例达CR(53％),6例达PR(28.5％),总有效率80.8％。主要的毒副作用为骨髓抑制,且抑制时间长。在此期间,积极给予支持治疗,注意预防和治疗并发症,一般不难度过。结论:未见明显的心脏毒性及肝肾损害,去甲氧柔红霉素是一种有效的抗白血病新药。
Objective: To study the anti-leukemia effect of rosoxyrubrin. METHODS: Twenty-one patients with refractory and relapsed acute leukemia were treated with a combination regimen consisting of drosinosinomycin. Results: 11 patients achieved CR (53%), 6 patients achieved PR (28.5%), and the total effective rate was 80.8%. The main toxic side effect is myelosuppression, and the inhibition is long. During this period, it is generally not difficult to give supportive treatment and pay attention to prevention and treatment of complications. Conclusion: There is no obvious cardiotoxicity and liver and kidney damage, and drosophilicin is an effective anti-leukemia drug.