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动态观察山羊假手术组 ( Sham)和双侧卵巢切除组 ( OVX)在术前、术后 3月、6月、12月和 18月不同时间段血清骨特异性碱性磷酸酶 ( B- AL P)、抗酒石酸酸性磷酸酶 ( TRAP)、血清骨钙素 ( BGP)、血清磷 ( P)、血清钙 ( Ca)的变化规律 ,以及术后 12月血清雌二醇 ( E2 )水平的改变和术后 6月、18月子宫与阴道重量的变化。结果显示 :Sham组术后 18月 B- AL P水平明显高于术前 ( P<0 .0 1) ,其余各时间段相比差异无显著性 ( P>0 .0 5 )。 Sham组中 TRAP、P、Ca各时间段亦无明显改变 ( P>0 .0 5 ) ;而 BGP在术后 3月下降 ,明显低于术前 ( P<0 .0 5 ) ,以后逐渐升高 ,恢复到术前水平。 OVX组 B- AL P在术后 3月出现增高 ,但与术前相比差异无显著性 ( P>0 .0 5 ) ;术后 6个月 B- ALP迅速增高 ,比术前升高 167% ( P<0 .0 1) ;此后 B- ALP仍缓慢上升 ,至后术后 18个月比术前升高 2 19% ( P<0 .0 1)。 OVX组术后 6月、12月和 18月与同时间段 Sham组相比 ,其 B- AL P水平差异有显著性 ( P<0 .0 5 ,P<0 .0 1)。 OVX组中TRAP在术后 3月比术前明显增高 ( P<0 .0 5 ) ;术后 6月增高最为明显 ( P<0 .0 1) ,与同时间段 Sham组相比也明显增高 ( P<0 .0 5 )。OVX组血清 P在术后 3月、12月比术前明显增高 ( P<0 .0 5 ) ;但血清
The changes of serum bone-specific alkaline phosphatase (B-AL) in sham-operated and ovariectomized (OVX) groups were observed before and 3 months, 6 months, 12 months and 18 months after operation (P <0.01), TRAP, BGP, serum Ca, and serum estradiol (E2) after 12 months And the change of uterus and vagina weight after 6 months and 18 months. The results showed that the level of B-ALP at 18 months after operation in Sham group was significantly higher than that before operation (P <0.01), while there was no significant difference between the other groups (P> 0.05). There were no significant changes in TRAP, P and Ca in Sham group at all time points (P> 0.05), but BGP decreased at 3 months postoperatively and was significantly lower than preoperative (P <0.05) High, returned to preoperative level. The level of B-ALP in OVX group increased at 3 months after operation, but there was no significant difference between before and after operation (P> 0.05). The B-ALP increased rapidly at 6 months after operation % (P <0.01). The level of B-ALP increased slowly thereafter, increasing by 19% (P <0.01) 18 months later than that before operation. The levels of B-ALP in OVX group at 6, 12 and 18 months after operation were significantly different from those in Sham group at the same time point (P <0.05, P <0.01). The level of TRAP in OVX group was significantly higher than that before operation (P <0.05) at 3 months after operation, and the most significant increase at 6 months after operation (P <0.01), which was also significantly higher than Sham group (P <0. 05). Serum P in OVX group was significantly higher than that before operation at 3 months and 12 months after operation (P <0.05)