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连续动态监测４２例重症感染合并成人呼吸窘迫综合征（ＡＲＤＳ）高危状态患者的肺换气功能５项指标（ＰａＯ＿２／ＦｉＯ＿２、ａ／ＡＰＯ＿２、Ｑｓ／Ｑｔ、ＲＩ及Ａ－ａＤＯ＿２），探讨各项换气功能指标在ＡＲＤＳ早期诊断中的意义。临床上将ＡＲＤＳ高危患者分为肺功能受损（Ⅰ组）、肺早期衰竭（Ⅱ组）及肺衰竭（Ⅲ组），结果：肺早期衰竭患者临床表现虽不明显，但肺内分流已＞１０％，ａ／ＡＰＯ＿２０．５～０．６，表明患者ＡＲＤＳ病理过程已经启动，且已进入肺衰竭。本研究资料经Ｂａｙｅｓ判别分析结果，Ⅱ与Ⅰ组的Ｆ值３６．２３，Ⅲ与Ⅰ组Ｆ值５１．２６，Ⅲ与Ⅱ组Ｆ值１５．７６。提示：３组间确有区别。被选中的自变量为不同病期时的呼吸次数、ＰａＯ＿２／ＦｉＯ＿２、ａ／ＡＰＯ＿２、ＲＩ和Ｑｓ／Ｑｔ。说明这些指标对ＡＲＤＳ的诊断具有参考价值。作者认为ＰａＯ＿２／ＦｉＯ＿２用以判别肺衰较单独使用ＰａＯ＿２更合理，并提出将ａ／ＡＰＯ＿２应用于临床则较Ａ－ａＤＯ＿２有其优点。
FiO2, a / APO2, Qs / Qt, RI and A-aDO2 were studied in 42 consecutive patients with severe respiratory infection (ARDS) at high risk of acute respiratory failure (ARDS) Significance of ventilatory function in early diagnosis of ARDS. Clinically, high-risk ARDS patients were divided into impaired lung function (group Ⅰ), early lung failure (group Ⅱ) and pulmonary failure (group Ⅲ). Results: Although the clinical manifestations of patients with pulmonary early failure were not obvious, 10%, a / APO_20.5 ~ 0.6, indicating that patients with ARDS pathological process has been started, and has entered the lung failure. The results of Bayes discriminant analysis in this study, the F value of Ⅱ and Ⅰ group 36.23, Ⅲ and Ⅰ group F value 51.26, Ⅲ and Ⅱ group F value 15.76. Tip: There are differences between the three groups. The variables selected were the number of breaths at different stages of disease, PaO 2 / FiO 2, a / APO 2, RI and Qs / Qt. These indicators of reference for the diagnosis of ARDS. The authors believe that PaO_2 / FiO_2 is more reasonable for discriminating pulmonary failure than PaO_2 alone, and suggests that the use of a / APO_2 in clinical practice has advantages over A-aDO_2.