目的了解金黄色葡萄球菌对矽肺患者临床常用抗菌药物的耐药情况,为临床合理用药提供参考。方法对各类感染标本分离的62株金黄色葡萄球菌,采用K-B纸片琼脂扩散法进行药敏试验;头孢西丁纸片扩散法筛选耐甲氧西林金黄色葡萄球菌(MRSA)。结果头孢西丁纸片扩散法共检出37株(59.7%)MRSA。MRSA对β内酰胺类抗生素耐药率较高,对青霉素、头孢西丁、头孢曲松、氨苄西林耐药率均达100%;MRSA和甲氧西林敏感金黄色葡萄球菌(MSSA)对大环内酯类、磺胺类抗生素均有不同程度耐药;复方新诺明对MRSA菌的敏感率比MSSA强得多,MRSA对其的敏感率达78.4%,MSSA对其的敏感率仅达8%;MRSA对红霉素的耐药率极高,达97.3%;MRSA和MSSA对万古霉素的敏感率均为100%。MRSA检出率为59.7%。结论临床分离的金黄色葡萄球菌对常用抗菌药物多重耐药,应根据分离株耐药特点选用不同的治疗方案;头孢西丁纸片扩散法筛选MRSA效果较好。 Objective To understand the resistance of Staphylococcus aureus to commonly used antimicrobial agents in patients with silicosis and to provide a reference for clinical rational drug use. Methods 62 strains of Staphylococcus aureus isolated from various infected specimens were susceptible tested by K-B agar diffusion method. Methicillin-resistant Staphylococcus aureus (MRSA) was screened by cefoxitin disk diffusion method. Results 37 (59.7%) MRSA strains were detected by cefoxitin disk diffusion method. MRSA resistant rate of β-lactam antibiotics is high, the rate of resistance to penicillin, cefoxitin, ceftriaxone and ampicillin reaches 100%; MRSA and methicillin-sensitive Staphylococcus aureus (MSSA) Lactones and sulfa antibiotics have different degrees of resistance; the cotrimoxazole MRSA susceptible rate is much higher than MSSA, MRSA sensitive rate of 78.4%, MSSA sensitive rate of only 8% The MRSA resistance to erythromycin was extremely high, reaching 97.3%. The sensitivity of MRSA and MSSA to vancomycin was 100%. MRSA detection rate was 59.7%. Conclusion Staphylococcus aureus clinical isolates commonly used antibacterial multi-drug resistance, should be based on the characteristics of drug-resistant isolates selection of different treatment options; cefoxitin disk diffusion screening screening MRSA better.