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幽门螺杆菌(HP)是引起人类胃肠疾病最常见的致病菌之一,其致病机制非常复杂,既涉及细菌因素,也涉及宿主因素。近年来,随着免疫学、生物技术的发展,越来越多的研究发现HP感染宿主后与胃黏膜上皮接触及定植,机体会产生较复杂的炎性免疫反应。但机体免疫反应并不能有效地清除细菌,且随感染持续而致病。机体胃肠道免疫系统在防御HP感染过程中起重要作用。现就HP感染与胃肠道免疫在黏膜组织、细胞及分子水平的免疫反应及调节予以综述。
Helicobacter pylori (HP) is one of the most common pathogenic bacteria causing gastrointestinal diseases in humans. Its pathogenic mechanism is very complicated, involving not only bacterial factors but also host factors. In recent years, with the development of immunology and biotechnology, more and more studies have found that HP infection host and gastric mucosal epithelium contact and colonization, the body will have a more complex inflammatory immune response. But the body’s immune response does not effectively remove bacteria, and with the infection continued to cause disease. The body’s gastrointestinal immune system plays an important role in the defense of HP infection. Now on the HP infection and gastrointestinal immune mucosal tissue, cellular and molecular level of immune response and are reviewed.