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对四环素类抗菌素在浓硫酸作用下的降解物脱水四环素类抗菌素与β－环糊精的相互作用进行了研究，发现脱水四环素，脱水土霉素能与β－环糊精形成包络物，而脱水金霉素和脱水强力霉素与β－环糊精的包络作用则十分微弱，从四环素类抗菌素和β－环糊精的分子结构出发，对包络物的形成机理进行了研究，分别测定了包络物的形成常数，建立了利用转化荧光结构法测定四环素、土霉素和甲烯土霉素这３种四环素类抗菌素的新方法，结果令人满意．
The interaction between tetracyclines and β-cyclodextrins, a degradation product of tetracycline antibiotics under concentrated sulfuric acid, was studied. It was found that dehydrated tetracycline and dehydrocotmycin could form envelop with β-cyclodextrin. The enveloping effect of desiccated chlortetracycline and dehydroxycycline and β-cyclodextrin was very weak. Based on the molecular structure of tetracycline antibiotics and β-cyclodextrin, the formation mechanism of envelop was studied respectively The formation constants of the envelop were determined and a new method for the determination of tetracycline, oxytetracycline and methacycline was established by the method of transformed fluorescence. The results were satisfactory.