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本文考察了三种不同类型界面活性剂月桂醇硫酸钠(SDS),吐温-80(TEN)及十六烷基三甲基溴化铵(CAB),对难溶性固体药物阿斯匹林(ASPN)片剂溶出速度的影响,并进一步探讨了其作用机制。实验表明界面活性剂CAB和TEN对ASPN具有改善润湿及反絮凝作用,可明显增加水中ASPN的溶解及其片剂的溶出,胶团增溶作用经测定是很有限的,不能说明ASPN水中溶解的显著增加。界面活性剂SDS对ASPN的润湿、增溶及其片剂的溶出均没有明显作用。认为与界面活性剂及药物分子的结构和性质密切相关。
Three different types of surfactant sodium lauryl sulfate (SDS), Tween-80 (TEN) and cetyltrimethylammonium bromide (CAB) were investigated in this paper. The effects of aspirin ASPN) tablet dissolution rate, and further explored its mechanism of action. The experiments show that the surfactants CAB and TEN can improve the wetting and deflocculation of ASPN, and can significantly increase the dissolution of ASPN in water and the dissolution of tablets. The determination of micellar solubilization has been limited and can not explain the dissolution of ASPN in water A significant increase. The surfactant SDS has no obvious effect on the wetting and solubilization of ASPN and the dissolution of its tablets. It is thought to be closely related to the structure and properties of surfactants and drug molecules.