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目的 评价化学治疗药物 (下称化疗药 )在肝癌治疗中的作用和地位。方法 采用MTT法测定 5 Fu、顺铂和 4 PA对肝癌细胞增殖的抑制作用。结果 (1) 5 Fu、顺铂两药分别单剂使用 ,在给药后 0 5h肝癌细胞增殖活跃 ,而 12h后肝癌细胞增殖均受到抑制 ;对氯苯乙酸在给药后0 5h肝癌细胞增殖即被抑制。 (2 )肝癌细胞抑制率随化疗药的作用时间延长而增加 ,48～ 72h达 5 0 %以上的抑制率。 (3)化疗药对肝癌细胞的作用早期 ,癌细胞的生长有返跳活跃阶段 ,但总体上癌细胞的生长被抑制。结论 连续用药可很好地抑制肝癌细胞增殖 ,提高恶性肿瘤化学药物治疗的效果。
Objective To evaluate the role and status of chemotherapy drugs (hereinafter referred to as chemotherapeutics) in the treatment of liver cancer. Methods The inhibitory effects of 5 Fu, cisplatin and 4 PA on the proliferation of hepatoma cells were determined by MTT assay. Results (1) When 5 Fu and Cisplatin were used as a single agent, the proliferation of hepatocellular carcinoma cells was active at 0 5 h after administration, while the proliferation of hepatoma cells was inhibited after 12 h; the proliferation of hepatoma cells was observed at 50 h after the administration of p-chlorophenylacetic acid. That is, it is suppressed. (2) The inhibition rate of hepatocellular carcinoma cells increases with the prolongation of the action time of chemotherapy drugs, and the inhibitory rate exceeds 50 % at 48 to 72 hours. (3) Early effects of chemotherapeutic drugs on hepatocarcinoma cells. The growth of cancer cells has an active phase of regurgitation, but overall the growth of cancer cells is inhibited. Conclusion Continuous drug treatment can inhibit the proliferation of hepatoma cells and improve the efficacy of chemotherapy for malignant tumors.