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自从应用H_2拮抗剂治疗酸性消化病,全世界每年销售约20亿美元。有证据提出这些药物产生CNS 作用,这可能与在CNS 中存在的专一性H_2受体相互作用有关。本文综述在临床上与组胺H_2受体拮抗剂有关的CNS综合征。
Since the H 2 antagonist is used to treat acidic digestive diseases, the world sells about 2 billion U.S. dollars annually. Evidence suggests that these drugs have a CNS effect, which may be related to the specific H 2 receptor interaction present in the CNS. This article reviews CNS syndromes that are clinically relevant to histamine H 2 receptor antagonists.