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目的探讨采用左氧氟沙星与抗结核化疗方案联合治疗复治痰涂片阳性肺结核的临床效果。方法选取贵州省遵义市湄潭县人民医院收治的100例痰涂片阳性肺结核患者作为研究对象,随机分为对照组和观察组,每组60例。对照组接受肺结核强化期治疗,观察组在肺结核强化期治疗的基础上,使用左氧氟沙星联合治疗。治疗结束后,通过检查患者的痰菌转阴率、病灶吸收率,分析判断两种治疗方案的临床效果。结果观察组患者在第2、3、5、8个月末痰涂片检测出的痰菌转阴率均高于对照组,差异有统计学意义(P<0.05);观察组患者总体病灶吸收率达到96.67%,远高于对照组的66.67%,差异有统计学意义(P<0.05)。结论左氧氟沙星与抗结核化疗方案联合治疗复治痰涂片阳性肺结核取得了较好的治疗效果,值得临床推广应用。
Objective To investigate the clinical efficacy of levofloxacin combined with anti-tuberculosis chemotherapy in the treatment of relapsed sputum smear-positive pulmonary tuberculosis. Methods 100 sputum smear-positive pulmonary tuberculosis patients admitted to Meitan County People’s Hospital of Zunyi City, Guizhou Province were selected as research object and randomly divided into control group and observation group, 60 cases in each group. The control group received intensive treatment of pulmonary tuberculosis. The observation group was treated with levofloxacin on the basis of the treatment of intensive pulmonary tuberculosis. After treatment, by examining the patient’s sputum negative rate, the rate of absorption of the lesion, the analysis to determine the clinical efficacy of the two treatment options. Results In the observation group, the sputum negative rate detected by sputum smear at the end of the 2nd, 3rd, 5th, and 8th months was higher than that of the control group (P <0.05). The overall absorption rate Reaching 96.67%, much higher than 66.67% of the control group, the difference was statistically significant (P <0.05). Conclusion Levofloxacin and anti-tuberculosis chemotherapy regimen combined treatment of sputum smear-positive pulmonary tuberculosis has achieved good therapeutic effect, it is worth clinical application.