论文部分内容阅读
目的探讨温州地区5岁以下住院患儿社区获得性肺炎(community acquired pneumonia,CAP)病毒病原学感染状况,为临床合理用药提供依据。方法 2009年2月—2010年1月在温州医学院附属育英儿童医院儿科确诊为CAP的5岁以下住院患儿,入院当天或次日清晨取其鼻咽部分泌物,采用直接免疫荧光法分别检测呼吸道合胞病毒(RSV)、腺病毒(ADV)、流感病毒A、B型(IVA、IVB)和副流感病毒Ⅰ、Ⅱ、Ⅲ型(PIV Ⅰ、PIV Ⅱ、PIV Ⅲ)7项呼吸道病毒抗原。结果 2247例患儿中,阳性843例,阳性率为37.52%。其中RSV 633例,占75.09%;PIV III 93例,占11.03%;IVA55例,占6.53%;PIV Ⅰ 22例,占2.61%;ADV 17例,占2.00%;IVB 6例,占0.71%;混合感染17例,占2.04%。结论 2009—2010年度温州地区5岁以下住院患儿CAP病毒病原以RSV为主,其次为PIV Ⅲ,IVA和PIV Ⅰ;病毒流行高峰为冬春季节;RSV的检出率从11月开始逐渐升高(23.16%),1、2月达高峰(分别为69.26%、49.81%),持续到次年4月(18.50%),以后逐渐下降,6、7月最低(均为1.01%)。婴幼儿是病毒性肺炎防治的重点。
Objective To investigate the etiological status of community acquired pneumonia (CAP) virus in children under 5 years of age in Wenzhou and to provide basis for clinical rational drug use. Methods From February 2009 to January 2010, nasopharyngeal secretions were collected on the day of admission or in the early morning of the following morning in hospitalized children under 5 years of age who were diagnosed as CAP in the Department of Pediatrics of Yuying Children’s Hospital Affiliated to Wenzhou Medical College from January 2009 to January 2010. The direct immunofluorescence method Seven respiratory viruses of respiratory syncytial virus (RSV), adenovirus (ADV), influenza virus A and B (IVA and IVB) and parainfluenza virus type I, II and III (PIVI, PIVII and PIVIII) antigen. Results Of 2247 cases, 843 were positive, the positive rate was 37.52%. Of these, 633 cases of RSV accounted for 75.09%, 93 cases of PIV III accounted for 11.03%, 55 cases of IVA accounted for 6.53%, 22 cases of PIV Ⅰ accounted for 2.61%, 17 cases of ADV accounted for 2.00%, 6 cases of IVB accounted for 0.71% Mixed infection in 17 cases, accounting for 2.04%. Conclusion The prevalence of CAP virus in infants under 5 years of age in Wenzhou in 2009-2010 was mainly RSV, followed by PIV Ⅲ, IVA and PIV Ⅰ. The peak of virus prevalence was in winter and spring. The detection rate of RSV gradually rose from November (23.16%) and peaked in January and February (69.26% and 49.81% respectively), continuing to April (18.50%) in the following April and gradually decreasing thereafter, with the lowest in June and July (both being 1.01%). Infants and young children is the focus of prevention and treatment of viral pneumonia.