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肾脏是铅毒性作用的靶器官。研究表明,慢性非特异性肾炎可提高铅中毒工人死亡的危险性。依地酸钙(Ca-EDTA)和二巯基丙醇(BAL)副作用较大,故对其治疗有肾功能障碍的铅中毒患者心有疑虑。二巯基丙磺酸盐(DMPS)是治疗铅中毒的有效药物,然而其效果及安全性则与肾脏功能有关。本实验研究了DMPS是否适用于治疗有肾损害的铅中毒患者。雄性ITRC大鼠,饮水中按10 mg/kg剂
Kidneys are the target organs for lead toxicity. Studies have shown that chronic non-specific nephritis can increase the risk of death from lead poisoning workers. Calcium EDTA (EDTA) and dimercaptopropanol (BAL) side effects, so its treatment of renal dysfunction in patients with heart poisoning have doubts. Dimercaptopropanesulfonate (DMPS) is an effective drug for the treatment of lead poisoning, however its efficacy and safety are related to renal function. This study investigated whether DMPS is suitable for the treatment of lead poisoning in patients with renal impairment. Male ITRC rats, drinking water at 10 mg / kg dose