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目的了解丙型肝炎患者的流行病学及临床特点。方法对387例确诊为丙型肝炎患者的临床资料采用回顾性的方法进行分析,研究该组人群感染HCV的传播途径、临床表现、病毒学特征。结果 387例患者中263例有输血及血制品应用史,占67.96%,32例有手术史,占8.27%,有偿献血者30例,占7.75%,有拔牙、洗牙、补牙史者15例,占3.88%;387例患者中,318例无明显症状和体征,占82.17%,209例肝功能正常,占54.01%,对291例患者的HCV RNA载量分级统计,以(5×104)~(5×105)拷贝/ml所占百分比最大,占42.61%,其中76例患者进行基因分型,1b型60例,占78.95%,2a型15例,占19.74%。结论丙型肝炎患者感染HCV多经输血及应用血制品途径,此外,洗牙、拔牙、补牙及纹眉、纹眼线、穿耳孔等亦可能是丙型肝炎感染途径;丙型肝炎患者大多无明显症状和体征,肝功能正常,病情隐匿;HCV常见的基因型以1b型为主,2a型其次。
Objective To understand the epidemiology and clinical features of hepatitis C patients. Methods The clinical data of 387 patients diagnosed with hepatitis C were analyzed retrospectively to investigate the transmission, clinical manifestation and virological characteristics of HCV infection in this group. Results Among the 387 patients, 263 cases had history of blood transfusion and blood products application, accounting for 67.96%, 32 cases had operation history, accounting for 8.27%, 30 cases were paid blood donation, accounting for 7.75%. There were 15 cases of tooth extraction, , Accounting for 3.88%. Among the 387 patients, there were no obvious symptoms and signs in 318 cases, accounting for 82.17%, 209 cases of normal liver function, accounting for 54.01%. The viral load classification of 291 patients was (5 × 104) ~ (5 × 105) copies / ml accounted for 42.61% of the total, of which 76 cases were genotyped, 60 cases of type 1b, accounting for 78.95%, type 2a 15 cases, accounting for 19.74%. Conclusions Hepatitis C patients are infected with HCV more than blood transfusions and blood products. In addition, scaling, extraction, fillings and eyebrows, eye lines and ear piercing may also be the pathways of hepatitis C infection. Most patients with hepatitis C have no obvious symptoms Symptoms and signs, liver function is normal, the condition is hidden; HCV common genotype 1b type, 2a type followed.