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同步放化疗是目前宫颈癌治疗的新进展,小剂量的化疗药物对放疗起到增敏的作用。就同步放化疗的机制、化疗方式、疗效及毒副反应进行综述。机制大致可概括为化疗抑制肿瘤细胞放疗后损伤的修复,减少对放疗不敏感的乏氧细胞的比例和促使肿瘤细胞同步化进入对放疗敏感的细胞周期。同步放化疗对宫颈癌的治疗效果优于单纯放疗,可提高宫颈癌患者的总生存率和无进展生存率,降低复发率,改善预后,增加手术机会和减少术中及术后并发症。由于化疗药物剂量小,故毒副反应不重,大多数患者可耐受。认为使用以顺铂为基础的同步放化疗方案效果更佳。其具体使用方法仍处于摸索阶段。
Concurrent radiotherapy and chemotherapy is the new progress of cervical cancer treatment, a small dose of chemotherapy drugs play an increasing role in radiotherapy. The mechanism of concurrent chemoradiotherapy, chemotherapy, efficacy and toxicity were reviewed. Mechanisms can be broadly summarized as chemotherapy that suppresses the repair of tumor cells after radiotherapy, reduces the proportion of hypoxic cells that are not sensitive to radiotherapy, and synchronizes the tumor cells into radiotherapy-sensitive cell cycles. The effect of concurrent chemoradiotherapy on cervical cancer is better than radiotherapy alone, which can improve the overall survival and progression-free survival of patients with cervical cancer, reduce the recurrence rate, improve the prognosis, increase the chance of operation and reduce the intraoperative and postoperative complications. Due to the small dose of chemotherapy drugs, so the toxicity is not heavy, most patients can tolerate. That the use of cisplatin-based concurrent chemoradiotherapy program is better. The specific method of use is still in the groping phase.