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目的探讨甘利欣在药物性肝功能异常治疗中的疗效。方法将91例药物性肝功异常者随机分为治疗组(47例)和对照组(44例)。对照组常规护肝治疗:口服护肝片肌苷和肝泰乐及静滴能量等;治疗组在对照组的基础上加用甘利欣静滴。结果肝功能恢复正常的平均天数,治疗组为(6.38±3.77)d,对照组为(11.25±5.08)d,两组比较差异有统计学意义(P<0.01);ALT、TB恢复正常平均天数,治疗组比对照组短(P<0.01)。结论甘利欣能有效地降低血清丙氨酸氨基转移酶及总胆红素,使肝功能迅速恢复正常。
Objective To investigate the efficacy of Glycyrrhizin in the treatment of drug-induced liver dysfunction. Methods Ninety-one patients with drug-induced liver dysfunction were randomly divided into treatment group (n = 47) and control group (n = 44). The control group conventional liver protection treatment: oral glycosaminoglycans and liver Tyle and intravenous infusion of energy; the treatment group in the control group based on the addition of Gan Li Xin intravenous infusion. Results The average number of days of normal liver function recovery was (6.38 ± 3.77) days in the treatment group and (11.25 ± 5.08) days in the control group, with significant difference between the two groups (P <0.01) , The treatment group shorter than the control group (P <0.01). Conclusion Glycyrrhizin can effectively reduce serum alanine aminotransferase and total bilirubin, the liver function returned to normal quickly.