最近的研究提示散发性包涵体肌炎的发病机制可能与免疫炎性反应、细胞变性、异常蛋白聚集、线粒体异常等有关,对于包涵体肌炎的诊断主要依赖病理诊断,免疫调节治疗可能有效。本文就包涵体肌炎发病机制的研究、临床表现及治疗等有关方面的最新进展进行了简要综述。 Recent studies suggest that the pathogenesis of sporadic inclusion body myositis may be associated with immune inflammatory reaction, cell degeneration, abnormal protein aggregation, mitochondrial abnormalities, etc., for the diagnosis of inclusion body myositis mainly depends on pathological diagnosis, immunomodulatory therapy may be effective. This article summarizes the recent progress in the study of the pathogenesis of inclusion body myositis, clinical manifestations and treatment.