论文部分内容阅读
环孢霉素A对肝脏、肾脏及心脏均有毒副作用,其对心脏的影响存在剂量及时间依赖的多向性。目前环孢霉素A对心脏毒性的具体机制尚不十分清楚,考虑可能与钙超载、线粒体损伤及氧化应激等因素相关。现综述其对心脏的双重影响及其毒性作用机制的研究进展。
Cyclosporine A has toxic and side effects on the liver, kidney and heart. Its effects on the heart are dose-and time-dependent. At present, the specific mechanism of the toxicity of cyclosporin A to cardiac is not yet fully understood, and may be related to factors such as calcium overload, mitochondrial damage and oxidative stress. Now review its double impact on the heart and its toxic mechanism of action research.