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The induction of MT(metallothionein) by Cd(II) and Zn(II) in renal proximal tubulecells (LLC-PKI) and the effects of simultaneous administration of Cd(II) and Zn(II) on MTinduction were discussed. The two metals administered together are able to induce MT toalmost 40 μg MT/mg protein. The additive production of MT may be due to two different effectsby Cd(II) and Zn(II) on the activation of MT transcription. The experiments of simultaneousadministration of Cd(II) and Zn(II) to the renal proximal tubule cells demonstrated the interactionof these metals, MT induction and proximal tubule toxicity.
The induction of MT (metallothionein) by Cd (II) and Zn (II) in renal proximal tubule cells (LLC-PKI) and the effects of simultaneous administration of Cd Administered together are able to induce MT toalmost 40 μg MT / mg protein. The additive production of MT may be due to two different effects by Cd (II) and Zn (II) on the activation of MT transcription. The experiments of simultaneous administration of Cd (II) II) and Zn (II) to the renal proximal tubule cells demonstrated the interaction of these metals, MT induction and proximal tubule toxicity.