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目的:检测慢性前列腺炎患者EPS中的尿酸(UA)水平并探讨其临床意义。方法:按NIH诊断标准确诊的91例慢性前列腺炎患者分为2组,ⅢA组(n=48)和ⅢB组(n=43)。对照组(n=22)为无慢性前列腺炎的健康志愿者。分别进行CPSI评分,EPS中WBC计数、pH值及UA浓度测定。结果:ⅢB组的EPS中UA浓度[(257.02±144.84)μmol/L]显著高于ⅢA组[(159.73±121.49)μmol/L,P<0.01]和对照组[(78.55±44.53)μmol/L,P<0.01]。EPS中UA水平与pH值之间呈负显著相关(r=-0.398,P<0.01),而与CPSI疼痛症状评分(CPSI-P)、排尿症状评分(CPSI-U)以及CPSI总分(CPSI-T)之间均呈显著正相关(r分别为0.436、0.316、0.403,P均<0.01)。结论:前列腺内的UA浓度升高可能会导致化学性炎症反应。EPS中的UA水平与慢性前列腺炎的症状相关。检测EPS中的UA水平对慢性前列腺炎的诊断和治疗具有重要意义。
Objective: To detect the level of uric acid (UA) in EPS of patients with chronic prostatitis and to investigate its clinical significance. Methods: Ninety-one patients with chronic prostatitis confirmed by NIH diagnostic criteria were divided into two groups: group ⅢA (n = 48) and group ⅢB (n = 43). The control group (n = 22) was a healthy volunteer without chronic prostatitis. CPSI score, EPS WBC count, pH and UA concentration were measured. Results: The concentration of UA in EPS in group ⅢB was significantly higher than that in group ⅢA [(159.73 ± 121.49) μmol / L, P <0.01] and that of control group [(78.55 ± 44.53) μmol / L , P <0.01]. The level of UA in EPS was negatively correlated with pH (r = -0.398, P <0.01), but not with CPSI score (CPSI-P), urination symptom score (CPSI-U) -T) (r = 0.436,0.316,0.403, P <0.01 respectively). Conclusion: Elevated UA in the prostate may result in a chemical inflammatory response. UA levels in EPS correlate with symptoms of chronic prostatitis. Detection of EPS UA levels in the diagnosis and treatment of chronic prostatitis is of great significance.