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盐酸 Bepridil 系一种较新的钙拮抗剂。本文对 bepridil 和习用钙拮抗剂的电生理学资料加以比较,并着重研究心律失常患者静脉注射 bepridil 的电生理学效应。习用钙拮抗剂的电生理学效应(1)体外作用:在离体心肌,异搏停、地尔硫(艹卓)和硝苯吡啶在对快速钠电流无明显影响的浓度下能按浓度依赖的方式阻止缓慢的内向电流,证实此类药物对心肌慢通道作用的选择性。但在较高浓度时,尤其是地尔硫(艹卓)或异搏停,快通道可受到不同程度的阻滞。但钙拮抗剂在其阻滞心房、心室或浦顷野纤维内慢通道的浓度时,对动作电位上升速率则无影响;同样,对这些组织的不应期亦无显著作用。钙拮抗剂在离体肌肉中最明显和最
Bepridil hydrochloride is a newer type of calcium antagonist. This article compares the electrophysiological data of bepridil with conventional calcium antagonists and focuses on the electrophysiological effects of intravenous bepridil in patients with arrhythmias. Electrophysiological effects of conventional calcium antagonists (1) In vitro effects: In vitro, in the isolated myocardium, verapamil, diltiazem and nifedipine at no significant effect on the rapid sodium current concentrations of concentration-dependent Way to stop the slow inward current confirms the selectivity of these drugs on the role of the slow pathway of the myocardium. However, at higher concentrations, especially diltiazem or verapamil, the fast pathway may be arrested to varying degrees. However, calcium antagonists had no effect on the rate of rise of action potential when they blocked the concentration of slow atrium in the atria, ventricles, or umbilical fibers; similarly, they did not have a significant effect on refractory periods in these tissues. Calcium antagonists in muscle in the most obvious and most