Atkin 1977年发现,第1号染色体C带大小的异态现象,在恶性肿瘤患者比对照组常见得多。本文研究了更多的病例,论述了第1号染色体C带大小的异态现象及臂间倒位与癌症之间可能的关系。作者以正常细胞(大多数为淋巴细胞)制作染色体标本,且采用Sumner (1972)的BSG法作C显带,共研究144人,其中肿瘤病人76名。每个病例至少以10个“恰当”的中期分裂相检验有无倒位。受检细胞的标准是,第1号染色体不太收缩(长度至少7微米)或在着丝点处有一定角度,并在每一个染色体的着丝点区见到一、二个小球。在倒位的染色体上,小球位于离末端1/3的地方,通常是对着切迹。结果(表1):76例恶性肿瘤病人中有异态现象者为41例(54％),而68例对照组 Atkin discovered in 1977 that the aberration of C-band size on chromosome 1 was much more common in malignant tumors than in controls. This article studies more cases and discusses the anomaly of C-band size on chromosome 1 and the possible relationship between arm inversion and cancer. The authors used the normal cells (most of the lymphocytes) to make chromosome specimens, and the use of Sumner (1972) BSG method for C banding, a total of 144 people, of which 76 cancer patients. At least 10 “appropriate” metaphases were tested in each case to determine if there was any reversal. The criteria for the cells to be examined is that the chromosome 1 is not very contracted (at least 7 microns in length) or at an angle to the centromere and one or two beads are seen on the centromere of each chromosome. On the inverted chromosome, the globule is located 1/3 of the way from the tip, usually against the notch. The results (Table 1): 76 cases of malignant tumor patients with abnormalities were 41 cases (54%), and 68 cases of control group