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目的探讨新生儿黄疸患儿血清蛋白电泳图谱的改变。方法采用法国Sebia琼脂糖凝胶电泳技术。结果实验组白蛋白和微球蛋白α1,α2百分比较对照组低(P<0.05);β和γ球蛋白百分比较对照组高(P<0.01)。日龄<72 h的新生儿黄疸组,日龄≥72 h的新生儿黄疸组进行比较,白蛋白和微球蛋白α1,α2组随着日龄的增大,含量减少较为显著(P<0.01),而β,γ球蛋白组含量增高则较为明显(P<0.01)。结论血清蛋白电泳图谱分析有助于判断新生儿血清蛋白的缺失情况,及时补充蛋白营养,提供蛋白营养支持,同时还有助于判断新生儿黄疸患儿血清蛋白各组份含量随着日龄的增大的变化情况,为临床医师诊治新生儿病理性黄疸提供帮助。
Objective To investigate the changes of serum protein electrophoresis patterns in neonates with jaundice. Methods France Sebia agarose gel electrophoresis technology. Results The percentages of albumin and microglobulin α1 and α2 in the experimental group were lower than those in the control group (P <0.05). The percentages of β and γ globulin in the experimental group were higher than those in the control group (P <0.01). Neonatal jaundice group at day <72 h and jaundice group at day ≥72 h had a significant reduction in content of albumin and microglobulin α1 and α2 groups with increasing age (P <0.01) ), While the content of β, γ globulin increased significantly (P <0.01). Conclusion The analysis of serum protein electrophoresis map is helpful to judge the loss of serum protein in neonates, to replenish protein nutrition in time and provide protein nutrition support, and also to determine the content of serum protein in neonatal jaundice children with age Increased changes in clinicians for the diagnosis and treatment of neonatal pathological jaundice help.