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目的探讨宫保散联合宫颈环形电切术(LEEP)治疗宫颈癌前病变并发高危型人乳头瘤病毒(HPV)感染的临床疗效。方法选取我院2014年5月至2017年5月妇科门诊收治的300例宫颈癌前病变并发HPV感染的患者,随机均分为观察组与对照组各150例。观察组采取宫保散局部外用联合LEEP技术治疗,对照组采取单纯的宫保散局部外用治疗,对比分析两组的疗效。结果两组患者疗效比较,结果显示观察组治疗总有效率100%,对照组为91.3%,对比差异具有统计学意义(P<0.05),观察组疗效优于对照组。结论宫保散清热解毒,抑菌杀虫,LEEP降低HPV病毒载量和CIN分级,两者联合作为治疗CIN并发HPV感染的方法具有创伤小、费用低、疗效好等特点,值得临床应用。
Objective To investigate the clinical efficacy of Gongbao Powder combined with cervical ring electrosurgical excision (LEEP) in the treatment of cervical precancerous lesions complicated with high-risk human papillomavirus (HPV) infection. Methods A total of 300 cases of cervical precancerous lesions complicated with HPV infection admitted to Gynecology Clinic from May 2014 to May 2017 in our hospital were randomly divided into observation group and control group with 150 cases each. The observation group to take Gongbao scattered external topical LEEP technology treatment, the control group to take a simple Gongbao scattered local topical treatment, compared the efficacy of the two groups. Results The curative effect of the two groups was compared. The results showed that the total effective rate of the observation group was 100% and that of the control group was 91.3%. The difference was statistically significant (P <0.05). The curative effect of the observation group was better than that of the control group. Conclusions Gongbao Powder is effective in preventing and treating bacteria and insects, and LEEP reduces HPV viral load and CIN grade. The combination of the two as a method for treating CIN complicated with HPV infection has the advantages of small trauma, low cost and good curative effect, which is worthy of clinical application.