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目的探讨乳胶凝集试验在小儿新型隐球菌性脑膜炎诊断中的临床应用价值。方法对25例可疑有新型隐球菌性脑膜炎患儿进行颅脑CT和脑脊液墨汁染色,并均采用乳胶凝集试验检测患儿隐球菌抗原,根据是否有隐球菌性脑膜炎将患儿分成两组:隐球菌性脑膜炎组(A组)及无隐球菌性脑膜炎组(B组),分析两组乳胶凝集试验对小儿新型隐球菌性脑膜炎诊断的敏感性和特异性。结果 A组有14例乳胶凝集试验阳性;B组有1例乳胶凝集试验阳性。乳胶凝集试验对小儿新型隐球菌性脑膜炎诊断的敏感性为87.5%,特异性为88.9%。结论乳胶凝集试验对小儿新型隐球菌性脑膜炎诊断敏感性和特异性均高,值得推广应用。
Objective To investigate the clinical value of latex agglutination test in the diagnosis of cryptococcal meningitis in children. Methods Twenty-five children with suspected neoformans meningitis developed brain CT and cerebrospinal fluid ink stains, and the latex agglutination test was used to detect cryptococcal antigen in children. According to the presence or absence of cryptococcal meningitis, the children were divided into two groups : Cryptococcal meningitis group (group A) and no cryptococcal meningitis group (group B). The sensitivity and specificity of two groups of latex agglutination test in the diagnosis of children with cryptococcal meningitis were analyzed. Results A group of 14 cases of latex agglutination test positive; B group 1 case of latex agglutination test was positive. Latex agglutination test on children with new cryptococcal meningitis diagnosis of sensitivity was 87.5%, specificity was 88.9%. Conclusion The latex agglutination test has high sensitivity and specificity for the diagnosis of Cryptococcus neoformans meningitis in children, which is worth popularizing and applying.