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目的:探讨抗核抗体(ANA)谱、可提取核抗原(ENA)抗体谱阳性对视神经脊髓炎(NMO)患者疾病复发及致残率的影响。方法:对48例NMO患者进行病例回顾性分析。结果:ANA谱和/或ENA抗体谱阳性组患者2年平均复发次数为2.89,阴性组视神经脊髓炎患者2年平均复发次数为1.52;2组患者首次发病EDSS运动系统功能评分差别无统计学意义,而2年后EDSS运动系统功能评分阳性组为3.26,阴性组为1.90,2组差别有统计学意义。结论:与抗核抗体谱阴性组相比,阳性组的NMO患者2年内复发次数多,致残率高,应长期给予患者积极的免疫抑制治疗。
Objective: To investigate the influence of anti-nuclear antibody (ANA) spectrum and anti-nuclear antigen (ENA) antibody spectrum on the recurrence and morbidity of optic neuromyelitis (NMO) patients. Methods: 48 cases of NMO patients were retrospectively analyzed. Results: The average number of 2-year recurrence in patients with positive ANA spectrum and / or ENA antibody spectrum was 2.89, and the average number of 2-year recurrence in patients with negative myeloma was 1.52. There was no significant difference in the scores of EDSS motor system scores between the two groups , While 2 years after the EDSS motor system function score positive group was 3.26, negative group was 1.90, 2 group difference was statistically significant. Conclusion: Compared with the negative group of anti-nuclear antibody, the positive group of NMO patients had more relapse within 2 years and high morbidity, and should be treated with active immunosuppressive therapy for a long time.